Suppression of T cell immunity and antibody production during virus infection and sepsis
- Funded by UK Research and Innovation (UKRI)
- Total publications:0 publications
Grant number: 2748405
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Key facts
Disease
COVID-19, UnspecifiedStart & end year
20222026Known Financial Commitments (USD)
$0Funder
UK Research and Innovation (UKRI)Principal Investigator
N/A
Research Location
United KingdomLead Research Institution
CARDIFF UNIVERSITYResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Immunity
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
The generation of protective antibodies against infection is dependent on "help" from CD4+ T follicular helper (TFH) cells which are elicited in response to bacteria and viruses, such as influenza and SARS CoV-2. However, these cells can decline when immune responses are over- exaggerated (sepsis). The student will use immunological techniques and innovative gene profiling strategies to examine why low numbers of CD4+ TFH cells correlate with poor outcome in sepsis