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Suppression of T cell immunity and antibody production during virus infection and sepsis

  • Funded by UK Research and Innovation (UKRI)
  • Total publications:0 publications

Grant number: 2748405

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Key facts

  • Disease

    COVID-19, Unspecified

  • Start & end year

    2022
    2026

  • Known Financial Commitments (USD)

    $0

  • Funder

    UK Research and Innovation (UKRI)

  • Research Location

    United Kingdom

  • Lead Research Institution

    CARDIFF UNIVERSITY

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The generation of protective antibodies against infection is dependent on "help" from CD4+ T follicular helper (TFH) cells which are elicited in response to bacteria and viruses, such as influenza and SARS CoV-2. However, these cells can decline when immune responses are over- exaggerated (sepsis). The student will use immunological techniques and innovative gene profiling strategies to examine why low numbers of CD4+ TFH cells correlate with poor outcome in sepsis