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Development of reverse genetic systems and mouse model for SARS-CoV-2

  • Funded by National Institutes of Health (NIH)
  • Total publications:0 publications

Grant number: 3R01AI134907-04S1

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2020
    2022

  • Known Financial Commitments (USD)

    $197,500

  • Funder

    National Institutes of Health (NIH)

  • Principal Investigator

    Ricardo Rajsbaum

  • Research Location

    United States of America

  • Lead Research Institution

    UNIVERSITY OF TEXAS MED BR GALVESTON

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

ABSTRACT The recent epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused global public health emergency. Rapid response to disease control and countermeasure development is a public health priority. Reverse genetic systems and animal models are essential tools for studying viral replication, pathogenesis, vaccine development, and antiviral discovery. The goals of this supplement project are to (i) establish the reverse genetic systems and (ii) generate a mouse pathogenesis model for SARS-CoV-2.