Discovery and Translational Sciences|Pneumonia & Pandemic Preparedness

Grant number: INV-042471

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Key facts

  • Disease

    COVID-19, Severe Acute Respiratory Syndrome (SARS)
  • Start & end year

    2022
    2025
  • Known Financial Commitments (USD)

    $488,994
  • Funder

    Gates Foundation
  • Principal Investigator

    N/A

  • Research Location

    India
  • Lead Research Institution

    Indian Institute of Science
  • Research Priority Alignment

    N/A
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

to determine preferred receptor binding domain structure as a Pan-sarbecovirus vaccine candidate

Publicationslinked via Europe PMC

Destabilising Effect of Class B CpG Adjuvants on Different Proteins and Vaccine Candidates.

Stabilizing Prefusion SARS-CoV-2 Spike by Destabilizing the Postfusion Conformation.

Enhancing Immunogenicity of a Thermostable, Efficacious SARS-CoV-2 Vaccine Formulation through Oligomerization and Adjuvant Choice.