Discovery and Translational Sciences|Pneumonia & Pandemic Preparedness | Pandemic PACT Tracker

Key facts

Disease
COVID-19, Severe Acute Respiratory Syndrome (SARS), Middle East respiratory syndrome coronavirus (MERS)
Start & end year
2021
2024
Known Financial Commitments (USD)
$2,900,000
Funder
Gates Foundation
Research Location
United States of America
Lead Research Institution
University of Texas at Austin
Research Priority Alignment
N/A

Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Immunity
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable

Abstract

to engineer potent S2 pan B-coronavirus immunogens and mABs with broad multi-functional activity

6 Publications linked via Europe PMC

Last Updated:4 days ago

View all publications at Europe PMC

Structural and functional characterization of a conserved cryptic epitope on SARS-CoV-2 spike S2 subunit.

Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses.

Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogens.

Concurrent Administration of COVID-19 and Influenza Vaccines Enhances Spike-Specific Antibody Responses.

Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge.

Understanding Fc function for rational vaccine design against pathogens.