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Pneumonia & Pandemic Preparedness

Grant number: INV-005180

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Key facts

  • Disease

    Bacterial infection caused by Klebsiella pneumonia

  • Start & end year

    2020
    2022

  • Known Financial Commitments (USD)

    $135,329

  • Funder

    Gates Foundation

  • Research Location

    United Kingdom

  • Lead Research Institution

    Liverpool School of Tropical Medicine

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen genomics, mutations and adaptations

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Newborns (birth to 1 month)

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

to whole genome sequence all Klebsiella pneumoniae associated with invasive disease isolated from neonates admitted to the Chatinkha neonatal unit between 1996-2019 in order to predict serotype and inform vaccine design

3 Publications linked via Europe PMC

Last Updated:4 days ago

View all publications at Europe PMC

Temporal genomic dynamics of sequence type 39 Klebsiella pneumoniae in a neonatal unit in Blantyre, Malawi.

Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: A meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage.

Longitudinal analysis within one hospital in sub-Saharan Africa over 20 years reveals repeated replacements of dominant clones of Klebsiella pneumoniae and stresses the importance to include temporal patterns for vaccine design considerations.