Pneumonia & Pandemic Preparedness

Key facts

Disease
Bacterial infection caused by Klebsiella pneumonia
Start & end year
2020
2025
Known Financial Commitments (USD)
$3,048,427
Funder
Gates Foundation
Research Location
United Kingdom
Lead Research Institution
University of Oxford
Research Priority Alignment
N/A

Research Category
Epidemiological studies
Research Subcategory
Disease surveillance & mapping
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable

Abstract

to develop a comprehensive platform for Klebsiella pneumoniae genomic surveillance, with a focus on informing vaccine development and development of a Klebsiella genomic epidemiology community

10 Publications linked via Europe PMC

Last Updated:a day ago

View all publications at Europe PMC

PgaR is a positive regulator of the pgaABCD biosynthetic operon in Klebsiella pneumoniae.

Cumulative cgMLST provides increased discrimination of nested phylogenetic groups.

Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters.

Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: A meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage.

Authors
Stanton TD, Keegan SP, Abdulahi JA, Amulele AV, Bates M, Heinz E, Hooda Y, Hu W, Jain K, Kanwar S, Magobo R, Olwagen CP, Tembo JM, Sonda T, Strysko J, Tigoi CC, Amin SA, Bittinger K, Cornick J, Foster-Nyarko E, Gumbi W, Hotwani A, Iqbal N, Jones SM, Kabir F, Khan W, Musyani CL, McGann CM, Mittal V, Moustafa AM, Musicha P, Mwansa JCL, Ndumba ML, Odih EE, Omuoyo DO, Pearse O, Phillips LT, Planet PJ, Rasool AA, Rodrigues CMC, Sands K, Tanmoy AM, Theiller E, Zuza AM, Basu S, Chan GJ, Iregbu KC, Mazarati JB, Alemayehu SS, Walsh TR, Zahra R, Dramowski A, Fwoloshi S, Labi AK, Madrid L, Obeng-Nkrumah N, Ojok D, Wadugu BD, Whitelaw AC, Bethou A, Bhargava A, Jindal A, Nanavati RN, Prasad PS, Sastry A, Farooqi JQ, Ghanchi N, Jehan F, Khan E, Agarwal RK, Aiken AM, Berkley JA, Coffin SE, Feasey NA, Govender NP, Hamer DH, Madhi SA, Nisar MI, Saha SK, Saha S, Sankar MJ, Wyres KL, Holt KE.
Publish Year
2026
Journal
PLoS medicine
DOI
10.1371/journal.pmed.1004879

View at Europe PMC

Monitoring antimicrobial resistance trends from global genomics data: amr.watch.

Authors
David S, Caballero JD, Couto N, Abudahab K, Alikhan NF, Yeats C, Underwood A, Molloy A, Connor D, Shane HM, Ashton PM, Grundmann H, Holden MTG, Feil EJ, Sia SB, Donado-Godoy P, Lingegowda RK, Okeke IN, Argimón S, Aanensen DM, NIHR Global Health Research Unit on Genomics and enabling data for the Surveillance of AMR.
Publish Year
2025
Journal
PLOS global public health
DOI
10.1371/journal.pgph.0005256

View at Europe PMC

Key facts

Abstract

10 Publications linked via Europe PMC

PgaR is a positive regulator of the pgaABCD biosynthetic operon in Klebsiella pneumoniae.

Cumulative cgMLST provides increased discrimination of nested phylogenetic groups.

Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters.

Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: A meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage.

Monitoring antimicrobial resistance trends from global genomics data: amr.watch.

Accurate genotyping of three major respiratory bacterial pathogens with ONT R10.4.1 long-read sequencing.

amr.watch – monitoring antimicrobial resistance trends from global genomics data

Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT.

Plasmids pick a bacterial partner before committing to conjugation.