Tenascin C has no influence on the course of pneumonia caused by the bacterium Klebsiella pneumoniae.

Our group has previously found that Intensive Care patients with sepsis more Tenascin C (TNC) have in their blood that IC patients without infection. We also knew that TNC can stimulate the immune response. It would help many sepsis patients if we could inhibit their immune response, but only if the bacteria are still well combated. We have therefore used a model in which mice with TNC or without TNC Sepsis developed as a result of pneumonia. This way we could see if these mice could fight the bacteria with a less intense immune response. Publication of data Our results show that the presence of TNC made no difference: the bacteria grew just as fast and the immune response was equally strong. This is important information - it shows that mechanisms that are demonstrated with bacterial proteins can work differently than in the presence of living bacteria. Publishing this data can prevent similar negative animal experiments.