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Addressing Critical Gaps in mpox epidemiology in DRC - The MOVIE and TRACE studies

Grant number: 101195270

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Key facts

  • Disease

    mpox

  • Start & end year

    2024
    2026

  • Known Financial Commitments (USD)

    $1,564,232.55

  • Funder

    European Commission

  • Principal Investigator

    MARKS Michael

  • Research Location

    United Kingdom

  • Lead Research Institution

    LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER

  • Research Priority Alignment

    N/A

  • Research Category

    Epidemiological studies

  • Research Subcategory

    Disease transmission dynamics

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

  • Mpox Research Priorities

    N/A

  • Mpox Research Sub Priorities

    N/A

Abstract

This proposal outlines two linked studies aimed at addressing the public health challenge of Mpox in the Democratic Republic of Congo (DRC). The MOVIE study focuses on understanding the kinetics of viral elimination shedding light on how MPXV interacts with host tissues and immune defences, which is crucial for developing containment strategies and potentially influencing endpoint selection in therapeutic trials. The TRACE study aims to determine secondary attack rates in MPXV outbreaks, assessing host susceptibility within specific populations, offering vital data to target interventions towards vulnerable groups and informing vaccine efforts by contributing to the assessment of vaccine efficacy endpoints.