Lost in translation: why flaviviruses induce cleavage of tRNAs
- Funded by National Health and Medical Research Council (NHMRC)
- Total publications:0 publications
Grant number: GA409739
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Key facts
Disease
Zika virus disease, West Nile Virus Infection…Start & end year
20252028Known Financial Commitments (USD)
$881,386.12Funder
National Health and Medical Research Council (NHMRC)Principal Investigator
N/A
Research Location
AustraliaLead Research Institution
The University of QueenslandResearch Priority Alignment
N/A
Research Category
Clinical characterisation and management
Research Subcategory
4b. 6a
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
The project will investigate the role of transfer RNA-derived fragments (tiRNAs) in the host response to infection with pathogenic flaviviruses West Nile, Japanese encephalitis, Zika, dengue and yellow fever. The main goal is to elucidate mechanisms of how these tiRNAs are generated during infection and how they contribute to the antiviral response. We will also assess the antiviral potential of tiRNAs against these viruses to inform further development of tiRNA-based flavivirus therapeutics.