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Lost in translation: why flaviviruses induce cleavage of tRNAs

  • Funded by National Health and Medical Research Council (NHMRC)
  • Total publications:0 publications

Grant number: GA409739

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Key facts

  • Disease

    Zika virus disease, West Nile Virus Infection…

  • Start & end year

    2025
    2028

  • Known Financial Commitments (USD)

    $881,386.12

  • Funder

    National Health and Medical Research Council (NHMRC)

  • Research Location

    Australia

  • Lead Research Institution

    The University of Queensland

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    4b. 6a

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The project will investigate the role of transfer RNA-derived fragments (tiRNAs) in the host response to infection with pathogenic flaviviruses West Nile, Japanese encephalitis, Zika, dengue and yellow fever. The main goal is to elucidate mechanisms of how these tiRNAs are generated during infection and how they contribute to the antiviral response. We will also assess the antiviral potential of tiRNAs against these viruses to inform further development of tiRNA-based flavivirus therapeutics.