Defining interactions of complement to uncover pan-therapeutic targets for diverse neuroinflammatory disorders
- Funded by National Health and Medical Research Council (NHMRC)
- Total publications:0 publications
Grant number: GA409888
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Key facts
Disease
Congenital infection caused by Zika virusStart & end year
20252027Known Financial Commitments (USD)
$822,941.27Funder
National Health and Medical Research Council (NHMRC)Principal Investigator
N/A
Research Location
AustraliaLead Research Institution
Flinders UniversityResearch Priority Alignment
N/A
Research Category
Clinical characterisation and management
Research Subcategory
Disease pathogenesis
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Children (1 year to 12 years)Newborns (birth to 1 month)
Vulnerable Population
Unspecified
Occupations of Interest
Not applicable
Abstract
Neurodegeneration and neuroinflammation is a common mechanism underlying many brain disorders. Our study has chosen 3 contrasting diseases: ZIKV-infection in the newborn, a mild brain injury similar to a concussion, and a genetic model of childhood dementia. In these diseases, evidence supports a role of the bodies 'complement' system in effecting the brain. We will assess the role, and new ways to regulate complement to prevent damage or dysfunction of the brain. This may lead to new therapies.