Intergenerational impacts of paternal immune activation on brain function and dysfunction
- Funded by National Health and Medical Research Council (NHMRC)
- Total publications:0 publications
Grant number: GA147140
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Key facts
Disease
COVID-19Start & end year
20212025Known Financial Commitments (USD)
$778,537.23Funder
National Health and Medical Research Council (NHMRC)Research Location
AustraliaLead Research Institution
University of MelbourneResearch Priority Alignment
N/A
Research Category
Clinical characterisation and managementResearch Subcategory
Disease pathogenesisSpecial Interest Tags
N/AStudy Type
Non-ClinicalClinical Trial Details
N/ABroad Policy Alignment
PendingAge Group
Not ApplicableVulnerable Population
Not applicableOccupations of Interest
Not applicable
Abstract
We recently discovered that infection of male mice with a parasite (Toxoplasma gondii) before conception can change the epigenetic information in the sperm and alter behaviour of the offspring. This is the first evidence that pathogenic infection in males can affect the next generation. We will investigate how infection with other major pathogens, including bacteria and the virus causing COVID-19, may affect sperm epigenetics and offspring health, including their brain function and dysfunction.