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Systems immunology approaches for the identification of biomarkers of susceptibility and immunity to severe dengue fever

  • Funded by National Health and Medical Research Council (NHMRC)
  • Total publications:0 publications

Grant number: GA409676

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Key facts

  • Disease

    Dengue

  • Start & end year

    2025
    2027

  • Known Financial Commitments (USD)

    $465,954.71

  • Funder

    National Health and Medical Research Council (NHMRC)

  • Principal Investigator

    N/A

  • Research Location

    Australia

  • Lead Research Institution

    Monash University

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

This project will apply a systems immunology approach to cohort studies of individuals with uncomplicated or severe dengue fever recruited at local hospitals in Indonesia. The project will uncover key correlates of immunity and processes leading to life-threatening dengue hemorrhagic fever. The results will inform the design and evaluation of new and safe dengue vaccines and aid the identification of biomarkers to develop diagnostic tools for early detection of cases at risk of severe dengue.