How the synergy between flavivirus protein and noncoding RNA defeats antiviral response

Flaviviruses represent a persistent threat with a devastating impact on human health. They have sophisticated mechanisms to subvert and control human antiviral response. One of them is by producing a noncoding RNA. In this project we will obtain an understanding of how these RNAs determine the ability of flaviviruses to evade immune response and establish infection in humans. The outcome will advance our understanding of flavivirus pathogenesis and inform future design of novel antivirals.