Dissecting the mechanisms of flavivirus neuro-pathogenesis using the systems biology approach

Flaviviruses are important pathogens that Include West Nile, Japanese encephalitis and Zika viruses. They can infect human brain causing severe neurological diseases. This project is aimed to identify the cells in the brain vulnerable to viral infection and elucidate the molecular processes affected by the viruses in the brain. This will explain why flaviviruses cause neurological disease and identify the molecules that can be targeted to prevent or mitigate infection in the brain.