Dissecting nuclear-mitochondrial interactions in Aedes aegypti and their effects on Wolbachia biocontrol methods
- Funded by National Health and Medical Research Council (NHMRC)
- Total publications:0 publications
Grant number: GA65859
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Key facts
Disease
DengueStart & end year
20202024Known Financial Commitments (USD)
$708,102.57Funder
National Health and Medical Research Council (NHMRC)Principal Investigator
N/A
Research Location
Australia, Viet NamLead Research Institution
Monash UniversityResearch Priority Alignment
N/A
Research Category
Animal and environmental research and research on diseases vectors
Research Subcategory
Vector biology
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
Wolbachia-based biocontrol methods are a promising approach to limit the transmission of mosquito-borne viruses such as dengue. All Wolbachia methods use the same strategy to introduce Wolbachia into wild mosquito populations, which results in diverged nuclear and mitochondrial genomes. We will use lab and field-based assays to determine if divergence between these two genomes impacts the efficacy of Wolbachia releases, and provide a data-driven policy for future Wolbachia-based interventions.