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Dissecting nuclear-mitochondrial interactions in Aedes aegypti and their effects on Wolbachia biocontrol methods

  • Funded by National Health and Medical Research Council (NHMRC)
  • Total publications:0 publications

Grant number: GA65859

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Key facts

  • Disease

    Dengue

  • Start & end year

    2020
    2024

  • Known Financial Commitments (USD)

    $708,102.57

  • Funder

    National Health and Medical Research Council (NHMRC)

  • Research Location

    Australia, Viet Nam

  • Lead Research Institution

    Monash University

  • Research Priority Alignment

    N/A

  • Research Category

    Animal and environmental research and research on diseases vectors

  • Research Subcategory

    Vector biology

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Wolbachia-based biocontrol methods are a promising approach to limit the transmission of mosquito-borne viruses such as dengue. All Wolbachia methods use the same strategy to introduce Wolbachia into wild mosquito populations, which results in diverged nuclear and mitochondrial genomes. We will use lab and field-based assays to determine if divergence between these two genomes impacts the efficacy of Wolbachia releases, and provide a data-driven policy for future Wolbachia-based interventions.