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Dengue virus resistance to Wolbachia

  • Funded by National Health and Medical Research Council (NHMRC)
  • Total publications:0 publications

Grant number: GA65947

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Key facts

  • Disease

    Dengue

  • Start & end year

    2020
    2022

  • Known Financial Commitments (USD)

    $429,137.87

  • Funder

    National Health and Medical Research Council (NHMRC)

  • Principal Investigator

    N/A

  • Research Location

    Australia

  • Lead Research Institution

    Monash University

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen genomics, mutations and adaptations

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

A promising method of biocontrol utilises the bacterium Wolbachia to inhibit transmission of mosquito-borne viruses such as dengue. However, viruses may evolve resistance to Wolbachia's inhibitory effects. We will use two novel methods to determine the mechanisms by which dengue may overcome Wolbachia, and identify genetic sequences in the virus that might lead to resistance. Our findings will guide current and future field trials for Wolbachia-carrying mosquitoes.