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Dissecting the impacts of the bacterial host versus plasmid on the AMR burden

  • Funded by National Health and Medical Research Council (NHMRC)
  • Total publications:0 publications

Grant number: GA201987

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Key facts

  • Disease

    Bacterial infection caused by Klebsiella pneumonia

  • Start & end year

    2022
    2026

  • Known Financial Commitments (USD)

    $469,313.04

  • Funder

    National Health and Medical Research Council (NHMRC)

  • Principal Investigator

    N/A

  • Research Location

    Australia

  • Lead Research Institution

    Monash University

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen genomics, mutations and adaptations

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Plasmids, mobile DNA, transmit antimicrobial resistance (AMR). This project will use an innovative approach of experimental evolution and the latest DNA and RNA sequencing technology to study how AMR plasmids spread and evolve in multidrug-resistant Klebsiella pneumoniae strains within different clinical settings. Expected outcomes include enhanced knowledge in bacterial-plasmid co-evolution critically needed for targeted surveillance, detection and control strategies to curb the spread of AMR.