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Understanding and exploiting the mechanism of action of a novel dengue virus inhibitor

  • Funded by National Health and Medical Research Council (NHMRC)
  • Total publications:0 publications

Grant number: GA352064

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Key facts

  • Disease

    Dengue

  • Start & end year

    2024
    2026

  • Known Financial Commitments (USD)

    $517,346.48

  • Funder

    National Health and Medical Research Council (NHMRC)

  • Principal Investigator

    N/A

  • Research Location

    Australia

  • Lead Research Institution

    Flinders University

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    N/A

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

There is an urgent need for safe and effective therapies to treat dengue virus (DENV) infection. Excitingly, potent and safe inhibitors that target the viral NS4B protein have recently been developed and are in advanced stages of clinical development. This project will employ advanced proteomics, molecular virology, high resolution microscopy and molecular modelling approaches to reveal new details about the of precise effects of these inhibitors and mechanisms of viral resistance.