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Gut leak and microbiome contribution to severe dengue disease

  • Funded by National Health and Medical Research Council (NHMRC)
  • Total publications:0 publications

Grant number: GA279504

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Key facts

  • Disease

    Dengue

  • Start & end year

    2023
    2026

  • Known Financial Commitments (USD)

    $452,676.62

  • Funder

    National Health and Medical Research Council (NHMRC)

  • Principal Investigator

    N/A

  • Research Location

    Australia

  • Lead Research Institution

    The University of Queensland

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    N/A

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Mosquito-borne dengue virus is a major health threat in tropical areas. When some patients are recovering from fever, their condition suddenly deteriorates with life-threatening bleeding and shock. We propose that severe disease is the result of virus-induced damage to the gut, allowing entry of bacterial products into the body. Together with collaborators in Thailand and Japan, we will investigate the impact of gut bacteria on dengue disease and possible probiotic treatments.