CRACing the role of the Flavivirus NS1 protein
- Funded by National Health and Medical Research Council (NHMRC)
- Total publications:0 publications
Grant number: GA279548
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Key facts
Disease
Dengue, OtherStart & end year
20232025Known Financial Commitments (USD)
$558,073.53Funder
National Health and Medical Research Council (NHMRC)Principal Investigator
N/A
Research Location
AustraliaLead Research Institution
The University of QueenslandResearch Priority Alignment
N/A
Research Category
Therapeutics research, development and implementation
Research Subcategory
N/A
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
In this proposal, we will investigate the mechanisms by which various forms of the dengue viral protein, NS1 physically interacts with lipids and cholesterol. This is a critically important interaction for efficient viral replication and so understanding the ways in which NS1 engages with these host cell components should provide important clues as to how we can disrupt this interaction and so design potential anti-viral strategies not only for dengue, but also other flaviviruses.