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Molecular and multi-omics assessment of Klebsiella pneumoniae response to bacteriophages

  • Funded by National Health and Medical Research Council (NHMRC)
  • Total publications:0 publications

Grant number: GA409777

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Key facts

  • Disease

    Bacterial infection caused by Klebsiella pneumonia

  • Start & end year

    2025
    2028

  • Known Financial Commitments (USD)

    $507,755.94

  • Funder

    National Health and Medical Research Council (NHMRC)

  • Research Location

    Australia, Germany

  • Lead Research Institution

    University of Sydney

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen genomics, mutations and adaptations

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Bacteriophages are natural predators of bacteria that can be safely used to treat serious multidrug resistant infections when antibiotics fail. This project aims at identifying the molecular mechanisms that lead to bacterial resistance to phage attack and reduced clearance during therapy, thereby defining the key requirements for selection of bacteriophages for successful treatment of life-threatening multidrug resistant infections caused by the high priority pathogen Klebsiella pneumoniae.