Understanding the adaptive evolution of pathogens to predict and so prevent or reduce drug resistance: A proof of concept study for dynamic residue network analysis with applications to SARS-CoV-2 Mpro

Grant number: N/A

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Key facts

  • Disease

    COVID-19, Disease X
  • start year

    2023
  • Known Financial Commitments (USD)

    $438.61
  • Funder

    Novo Nordisk Foundation
  • Principal Investigator

    N/A

  • Research Location

    South Africa
  • Lead Research Institution

    Rhodes University
  • Research Priority Alignment

    N/A
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen genomics, mutations and adaptations

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Publicationslinked via Europe PMC

The Skills to Manage Pain Randomized Trial: Results of Antiretroviral Therapy Adherence, HIV Primary Care Retention, and Virologic Suppression Outcomes.

A reanalysis of population dynamics in the Casas Grandes region of Northern Mexico using mitochondrial DNA.

Action painting under spectroscopic light: Excited-state exchange interactions behind the vibrant blue in Jackson Pollock's <i>Number 1A, 1948</i>.

Improving the efficacy of anti-SSEA4 antibody in pancreatic cancer immunotherapy with glyco-optimization and immune checkpoint blockade.

Clenbuterol induces lean mass and muscle protein accretion, but attenuates cardiorespiratory fitness and desensitizes muscle β<sub>2</sub>-adrenergic signalling.

Posttranscriptional control of the B cell receptor by HuR is essential for innate B cell maintenance and function.

Five-year results of the SCENT trial with Surpass flow diverters to treat large or giant wide-neck aneurysms.

Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer.

Intention judgments are not a reliable measure of intuitive preferences.