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Sequencing and analysis of Estonian SARS-CoV-2 whole genomes 2022

Grant number: KoroGeno-EST-2022

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2022
    2022

  • Known Financial Commitments (USD)

    $1,249,558.59

  • Funder

    Estonian Research Council

  • Principal Investigator

    Lutsar Irja

  • Research Location

    Estonia

  • Lead Research Institution

    University of Tartu

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen genomics, mutations and adaptations

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The aim of KoroGeno-EST-2022 is to sequence and conduct molecular-epidemiology analysis for more than 8700 SARS-CoV-2 full genomes from the 1st of January to 31st of December 2022 in Estonia. Number of weekly sequenced strains depends directly on epidemiological situation including number of newly diagnosed SARS-CoV-2 cases as well as the need to monitor clinically, demographically or mutationally significant strains. Based on sequenced samples weekly reports will be prepared for Estonian Health Board (TA) and ECDC. In collaboration with TA SARS-CoV-2 genomic data will be used to analyze infection clusters to trace newly infected subjects. In addition, study will identify the prevalence of variants associated with higher pathogenicity or infectiousness or corresponding mutations. Based on these data authorities will get a better overview about circulating SARS-CoV-2 strains as well as imported cases. In general, current study will give significant contribution to the governmental decision-making process, and help more efficiently suppress the spread of COVID-19 epidemic.