Niclosamide Intramuscular Depot Injection for Dengue Virus Disease

Daewoong Therapeutics aims to repurpose niclosamide as an intramuscular depot injection effective against all four serotypes of dengue virus. This project assesses the activity of the compounds on dengue serotypes and performs in vivo efficacy studies in a dengue mouse model. The development of these therapeutics against the dengue virus is in response to the lack of available dengue treatments, and would be a complementary option to vaccines.