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B cell Epitope Discovery and Mechanisms of Antibody Protection for Enterovirus and Bunyavirus Entry Proteins

  • Funded by National Institutes of Health (NIH)
  • Total publications:0 publications

Grant number: 75N93024C00071-P00001-9999-1

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Key facts

  • Disease

    Unspecified

  • Start & end year

    2024
    2026

  • Known Financial Commitments (USD)

    $1,722,325

  • Funder

    National Institutes of Health (NIH)

  • Principal Investigator

    N/A

  • Research Location

    United States of America

  • Lead Research Institution

    INTEGRAL MOLECULAR

  • Research Priority Alignment

    N/A

  • Research Category

    N/A

  • Research Subcategory

    N/A

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The goal of proposal is to identify antibody epitopes that describe the human immune response to pathogens and other diseases and the mechanisms by which these epitopes provide protection against infection. Understanding antibody epitopes (i.e. how antibodies bind to their target) has led directly to improved vaccines, new antibody-based therapeutics, more specific diagnostics, and a better understanding of disease pathogenesis. This proposal will focus on discovery and characterization of B cell epitopes for Enterovirus and Bunyavirus Entry Proteins.