Return to homepagePandemic Pact

Project-003

  • Funded by National Institutes of Health (NIH)
  • Total publications:0 publications

Grant number: 5P01AI175399-03

Grant search

Key facts

  • Disease

    COVID-19

  • Start & end year

    2024
    2029

  • Known Financial Commitments (USD)

    $651,667

  • Funder

    National Institutes of Health (NIH)

  • Principal Investigator

    PROFESSOR Amal Amer

  • Research Location

    United States of America

  • Lead Research Institution

    OHIO STATE UNIVERSITY

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Post acute and long term health consequences

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

PROJECT 2 - SUMMARY COVID-19 is caused by pulmonary infection with SARS-CoV-2 virus and has become a world- wide health problem. More than 6 million people passed away and among the survivors, 33% complain from symptoms that do not disappear after the acute phase of infection which is called Long-COVID. Notably, during infection, patients with COVID-19 suffer from thrombi in the lung and the brain which were implicated in the symptoms of long COVID. Our project will improve our understanding for the contribution of our innate immune system to thrombus formation and cytokine storm during SARS-CoV-2 infection in the brain and the blood circulation. We will also test suitable inhibitors in collaboration with other projects in this Program. Together, this project will provide novel information on immunothrombosis and brain pathology during COVID-19 that will allow the design of new therapeutic targets.