Preparedness, Research and Surveillance Network for infectious Diseases in Central Africa

Since 2009, EDCTP has supported regional networks of excellence to build capacity for ICH-GCP-compliant clinical trials in Central Africa. The Central Africa Clinical Research Network (CANTAM, later CACTR), coordinated by FCRM, was the first of these initiatives, and has since grown into a critical, recognized partner for multicentre research, training, and outbreak response. Over the years, additional institutions have joined, clinical trials have been conducted, regulatory and ethics bodies strengthened, and new skills embedded to attract investment in health research. Yet, the COVID-19 pandemic and recurrent outbreaks of Ebola, cholera, and mpox in the DRC, RoC, and Cameroon highlight persisting vulnerabilities: limited diagnostic capacity, workforce shortages, fragmented research systems, and weak cross-border coordination. Against this backdrop, the PRESERVE consortium will consolidate and expand regional preparedness through an integrated programme that focuses on: Expertise - Validating innovative diagnostics for TB, arboviruses, and re-emerging infections, while improving febrile illness management and clinical care. Training and capacity building - Embedding a One Health approach through INOHA, Central Africa's first One Health institute; delivering bilingual MSc, PhD, and postdoctoral training; and strengthening mentorship and workforce development. Infrastructure - Upgrading National Public Health Laboratories, enhancing surveillance platforms, and ensuring sustainable accreditation and quality management systems. Partnerships - Deepening collaboration with Africa CDC, WHO-AFRO, CEPI, BMGF, PEPFAR, the Global Health Network, and national authorities to translate research into policy and ensure sustainability. PRESERVE builds accredited labs, open data, and skilled teams to enable rapid diagnosis, response, and a resilient, regionally owned outbreak platform with sustained impact.