Return to homepagePandemic Pact

growing up in a pandemic: trajectories of mental health from childhood to early adulthood in the context of covid19

Grant number: 20108

Grant search

Key facts

  • Disease

    COVID-19
  • Start & end year

    2021
  • Known Financial Commitments (USD)

    $306,620.39
  • Funder

    HRB Ireland
  • Principal Investigator

    Professor Ross Macmillan
  • Research Location

    Ireland
  • Lead Research Institution

    University of Limerick
  • Research Priority Alignment

    N/A
  • Research Category

    Secondary impacts of disease, response & control measures

  • Research Subcategory

    Indirect health impacts

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Adolescent (13 years to 17 years)Children (1 year to 12 years)

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

While it is well-established that early psychological well-being predicts later mental health, the role of broad, pervasive environmental stressors in such processes is less understood. Most important, few studies link environmental exposures like the pandemic and its associated social restrictions with developmental processes that give them unique meaning and consequences. This research examines how the pandemic/lockdown conditions have variable effects on mental health and illuminates the mechanisms at work. To do so, we exploit the unique design of the Growing up in Ireland study - one cohort studied from age 3 to 13 and another studied from age 9 to 22. We use three complementary strategies: Model trajectories of psychological well-being through the COVID-19 period in relation to different types of exposures to the pandemic and indicators of pre-pandemic risk and resilience and compare models across cohorts and genders. Identify sub-groups hat have unique patterns of psychological well-being over time (e.g., poor and stable, declining) within the pre-pandemic GUI data using growth mixture modelling and combine these with the exposure measures and measures of risk and resilience to predict pandemic related mental health across cohorts and gender. Strengthen causal inference of pandemic/lockdown exposures by applying a "difference-in-difference" approach to complementary panels for the two cohorts spanning ages 9 to 12/13 with only the younger cohort exposed to the pandemic. Identifying heterogeneity in the developmental consequences of exposure to the pandemic and the mechanisms that ameliorate or exacerbate its effects has important implications for policy and interventions to support psychological well-being. With explicit attention to social differentiation - by gender, socioeconomic status, disability, nativity, urban/rural location, and family structure - the research provides a tight lens on the implications of the pandemic/lockdown for psychological well-being and identifies sources of risk and resilience that either exacerbate or ameliorate the consequences of exposure.

21 Publications linked via Europe PMC

Molecular Mechanisms Involved in the B Cell Growth and Clonogenic Activity of HIV-1 Matrix Protein p17 Variants.

Molecular mechanisms behind the generation of pro-oncogenic HIV-1 matrix protein p17 variants.

The HIV-1 Matrix Protein p17 Does Cross the Blood-Brain Barrier.

Binding to PI(4,5)P2 is indispensable for secretion of B-cell clonogenic HIV-1 matrix protein p17 variants.

Evolution toward beta common chain receptor usage links the matrix proteins of HIV-1 and its ancestors to human erythropoietin.

B-cell clonogenic activity of HIV-1 p17 variants is driven by PAR1-mediated EGF transactivation.

Changes on the phytochemicals profile of instant corn flours obtained by traditional nixtamalization and ohmic heating process.

Identification of amino acid residues critical for the B cell growth-promoting activity of HIV-1 matrix protein p17 variants.

Functional properties and sensory value of snack bars added with common bean flour as a source of bioactive compounds