Participants' Research Ethics Toolbox (PRET) for the mpox response

This project involves training research stakeholders in the Democratic Republic of Congo (DRC) on use of the Participants' Research Ethics Toolbox (PRET), to support potential research participants' understanding and assertion of their rights in the current Mpox emergency and beyond. What did the study set out to achieve? The study aimed to build capacity for ethical research conduct in the Democratic Republic of Congo (DRC) by training community leaders, research stakeholders, and ethics committee members on the Participants' Research Ethics Toolbox (PRET) . The PRET is an open‑access set of tools that includes videos, posters, and discussion activities. It was originally developed in collaboration with Ebola survivor groups following the 2014 to 2016 Ebola outbreak and is designed to support adults with limited literacy to understand research processes, consent considerations, and research participants' rights. In this study, PRET was applied in the context of Mpox‑affected communities. The study objectives included delivering train‑the‑trainer workshops, supporting community leaders to lead PRET‑based discussions in their own contexts, and disseminating PRET among researchers and research governance stakeholders involved in public health emergency research. What were the key findings? Two in‑person train‑the‑trainer workshops were delivered in Kinshasa in June 2025, involving 40 community and religious leaders affiliated with the CONERELA+ network. Participants completed post‑workshop questionnaires and provided verbal feedback during facilitated sessions. The feedback indicated increased self‑reported understanding of research participants' rights, differences between healthcare and research, and processes related to research participation. Participants also reported feeling able to use and share PRET materials within their communities. Feedback from workshop participants informed the development of additional PRET resources. These included a research participant commitments poster, workshop planning materials, and the scripting of an additional video explaining why Mpox vaccine trials are conducted. Dissemination activities included an in‑person orientation to PRET at the University of Kinshasa involving approximately 100 research trainees and research governance stakeholders, as well as conference and virtual presentations with regional and international research actors. read blog What does this mean for policymakers and practitioners? The study provides an example of how PRET was used within training and dissemination activities involving community leaders, researchers, and ethics governance stakeholders during a public health emergency. Activities included engagement with national ethics stakeholders in the DRC, including members of the National Health Research Ethics Committee, in relation to awareness and potential future use of PRET within ethics training and engagement processes. The study also documented that community leaders trained through the train‑the‑trainer workshops intended to lead further PRET‑based sessions, subject to the availability of resources and institutional support. These activities are relevant to policymakers and practitioners involved in public health emergency research who are considering approaches to community engagement, ethics education, and sharing information about research participants' rights.