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Evaluation of the SARS-CoV-2 infection diagnostic performance of an exhaled air sample by R-tube technique in immunocompromised patients compared to broncho-alveolar lavage

  • Funded by Agence nationale de recherche sur le sida et les hépatites virale [National Agency for AIDS Research] (ANRS)
  • Total publications:0 publications

Grant number: ECTZ366101

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2025

  • Known Financial Commitments (USD)

    $241,298.37

  • Funder

    Agence nationale de recherche sur le sida et les hépatites virale [National Agency for AIDS Research] (ANRS)

  • Principal Investigator

    LACOMBE Karine

  • Research Location

    France

  • Lead Research Institution

    APHP-Sorbonne Université hôpital Saint-Antoine

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Diagnostics

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Individuals with multimorbidity

  • Occupations of Interest

    Unspecified

Abstract

"Main objective: Evaluation of the diagnostic performance of RTube technology compared with BAL in immunosuppressed patients with clinical and radiological suspicion of oCOVID-19 and negative nasopharyngeal PCR: Sensitivity, specificity of RTube test compared to BAL test as reference Secondary objectives: Acceptability and safety: absolute number, percentages of reported inconvenience by a self-questionnaire completed after the RTube sampling. Description of the clinical characteristics of oCOVID-19 patients: absolute number, percentages of reported symptoms (fever, cough, dyspnea, fatigue), delay from symptoms onset to BAL, medical history of the patients, current treatments... Description of the viral evolution by systematical SARS-CoV-2 sequencing Description of the intrapulmonary immunological response: concentration of pro-inflammatory cytokines Design of the study Diagnostic performances study"